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Showing posts with label Medical Science. Show all posts
Showing posts with label Medical Science. Show all posts

Edward Jenner

Science/Scientist Datebook: May 17

English Physician, Pioneer of Vaccination


Edward Anthony Jenner (1749-1823), was born on 17 May 1749 in Berkeley Gloucestershire. He also died there. Widely referred to as the "Father of Immunology," he is credited as the pioneer of smallpox vaccine. He developed vaccination to prevent smallpox.

Aware that a cowpox infection seemed to protect people from subsequent smallpox infection , he inoculated a healthy boy with cowpox. As a result, the boy developed a mild disease but months later the boy did not develop the disease after Jenner vaccinated against it.

His pioneering work in smallpox vaccine established vaccination as an invaluable medical tool.

Sources:
  • McGovern, Una, Ed. Biographical Dictionary, 6th Edition.  Edinburgh: Chambers, 2002
  • Ellyard, David. Who Discovered What When.  Sydney: New Holland, 2005

Image Credit:

Wikimedia Commons (Public Domain)

First Oral Contraceptive Pill


The pill for birth control, a single pill for drugs and sex.


On May 9, 1960, the United States Food and Drug Administration (FDA ) approved the birth control pill for use. Two days later, Enovid, the first oral contraceptive went on sale.

No one can fully say that the approval of this birth control pill could have prompted the sexual revolution.

Arthur Kornberg

Nobel laureate for DNA and RNA discoveries




Biochemist Arthur Kornberg specialized in molecular biology. His primary research interests were in biochemistry, especially enzyme chemistry, deoxyribonucleic acid synthesis (DNA replication) and studying the nucleic acids which control heredity in animals, plants, bacteria and viruses.

He was co-awarded the Nobel Prize in Physiology or Medicine 1959 for "discovery of the mechanisms in the biological synthesis of ribonucleic acid (RNA) and deoxyribonucleic acid together with Dr. Severo Ochoa of New York University.

Peyton Rous

Great Scientist 

American Pathologist, Nobel Laureate for his discovery of cancer being caused by viruses.



Francis Peyton Rous (October 5, 1879 – February 16, 1970) was born in Baltimore, Maryland and received his B.A. and M.D. from John Hopkins University. He joined the Rockefeller Institute for Medical Research in New York in 1909 and staying throughout his career.

Rous was involved in the discovery of the role of viruses in the transmission of certain types of cancer. In 1966 he was awarded a Nobel Prize in Physiology or Medicine "for his discovery of tumor-inducing viruses.

Otto Heinrich Warburg

Science / Scientist Datebook: October 8

 

Biochemist, Medical Doctor, and Nobel Laureate


Otto Heinrich Warburg (October 8, 1883 – August 1, 1970), a German physiologist, medical doctor and Nobel laureate, was the son of physicist Emil Warburg.  One of the 20th century's leading biochemists, his combined work in plant physiology, cell metabolism and oncology made him an integral figure in the later development of systems biology. He also worked with Dean Burk in photosynthesis to discover the I-quantum reaction that splits the carbon dioxide (CO2), activated by the respiration.

He won the Nobel Prize of 1931. An officer in the elite Ulan (cavalry regiment) during the First World War, he won the Iron Cross (1st Class) for bravery.

Andreas Vesalius and De Humani Corporis Fabrica



Andreas Vesalius was a Belgian physician, anatomist and teacher. He is the founder of modern human anatomy, and is famous for his textbook Fabrica, considered the greatest medical book in his time. The actual name of the book is De humani corporis fabrica (On the Fabric of the Human Body), written in 1543.


In the early 16th century, before Vesalius came into the medical scene, knowledge of human anatomy was based essentially on guesswork, and surgery was something unheard of. Medical students learned human anatomy not by studying bodies and dissecting them, but by reading the works of the Roman physician Galen (AD129-c. 216), considered a great authority at that time. The Greek philosopher Aristotle also studied anatomy closely, and, along with Leonardo da Vinci, was another forerunner of Vesalius.


Vesalius Challenges the Human Anatomy Dissection Process


One of the problems before Vesalius was the taboo on dissecting human bodies. A 14th century Bolognese doctor called Mondino DeLuzzi was one of the first to carry out a dissection. With his work, Vesalius broke two taboos.
  • First, Vesalius challenged the more than one thousand year old authority of Galen.
  • Second, Vesalius actually dissected human bodies, looking at anatomy closely, and encouraged his students to do the same.
The anatomical knowledge Vesalius gained was put into his great  book Fabrica, which laid the foundations of modern medicine.

Early Life of Andreas Vesalius


Andreas Vesalius (December 31, 1514 – October 15, 1564) was born into a Flemish family in Brussels, Belgium. His father was a court official in the service of the Holy Roman Emperor, and so was his grandfather. His ambition was to emulate them by serving his country.

As a teenager, he began medical studies at Louvain University in Brussels, and his desire to study anatomy was already evident. At the age of 16, he was stealing corpses for dissection in the middle of the night. In 1533, when he went to study in Paris, his pursuit was even gruesome. He scoured graveyards to find fresh bodies, and sometimes secretly dissected them in his room to avoid attention.

Despite what may appear to be an appalling pursuit, the anatomical knowledge he gained by dissecting cadavers paid off. In Paris, his skill came to the attention of university professors Jacob Sylvius and John Guinter, the two greatest anatomists in Europe at the time. Aged 23, Vesalius was made Head of the Department of Surgery and Anatomy of the University of Padua in Italy, which was then the most prestigious medical school in the world.

Vesalius Performs Dissection in Padua, Italy

Unlike Galen, Vesalius opted to perform the dissection himself while describing to his students exactly what he was uncovering and discovering.

In 1538, Vesalius got an artist, John Stephanus of Calcar, to draw versions of six of the charts he had sketched for his students. Published as Tabulae anatomicae sex (Six anatomical charts), three of these charts showed views of the human skeleton, while the other three showed:
  1. The portal vein near the heart
  2. The heart and all the body’s veins
  3. The heart and all the arteries.
The Tabulae was an instant hit, and Vesalius’s reputation as an anatomist grew. For four years, he embarked on a huge project to create a comprehensive and accurate guide to human anatomy based on dissections, and worked with a brilliant team of artists to that end. After everything was prepared, he sent the manuscript in Basel to John Oporinus, a distinguished professor and printer, with Vesalius’s orders to use the finest paper and best typography.
At age 29, Andreas Vesalius finished De humani corporis fabrica, libri septem (in seven volumes). Vesalius sent a magnificent purple silk-bound presentation copy to Emperor Charles V, complete with over 200 fabulous hand-coloured illustrations. The Emperor was so impressed that within a few months, he invited Vesalius to become the Emperor’s Personal Physician.

The Royal Physician Gives up Academic Career


Bronze Statue of Andreas Vesalius in Brussels, Belgium: Image by infomatique
In less than a year, Vesalius abandoned his academic career entirely. Having achieved his ambition to become a court official, he settled down to a distinguished but conservative career, marrying a Brussels girl, Anne van Hamme. The couple had a child, also named Anne.

Over the years, Andreas Vesalius became a highly distinguished physician respected across Europe. He was summoned by royalties to help court physicians, including Henry II of France, and Don Carlos, the Crown Prince of Spain.

Final Years of Andreas Vesalius


In 1564, Vesalius set out on a pilgrimage to the Holy Land for unknown reasons. The man who revolutionized the study of anatomy never returned, dying on the ship on his way home from Jerusalem.

His famous textbook, De humani corporis fabrica, or Fabrica in short, is still acclaimed for its highly detailed illustrations of human dissections, often represented in allegorical poses.


Resources: 

1. McGovern, Una. (ed). Chambers Biographical 
2. Chambers Dictionary. Chambers. (2002).
3. Farndon, J., et al. The Great Scientists. Capella / Arcturus. (2005).

Note: This article was originally published at Suite101.com, September 7, 2008.


(c)  September 2011. Tel. Inspired Pen Web. Inspired Pen Web.

First IVF Baby, Louise Joy Brown

Birth of the first IVF baby, Louise Joy Brown

Louise Joy Brown, the world's first in vitro fertilization (IVF), was born July 25, 1978. She was normal, except for the fact that she had been conceived outside her mother's body.

The physicians, Dr. Patrick Steptoe and Dr. Robert Edwards, took an egg from Lesley, Louise's mother, and fertilized it in a laboratory vessel, with sperm from John, the baby's father. Two days later, the embryo was implanted in Lesley Brown's womb. By the time Louise was 21, thousands of women had conceived with the help of IVF techniques.

Resource:
Dateline. Sydney Millenium House P/L, 2006

Vaccination of Children Against Polio

The first mass vaccination of children against polio begins this day, February 23, 1954, in Pittsburgh, Pennsylvania

Until the 1950s was anxious times for parents because at that time children became infested with a crippling disease referred to as poliomyelitis, or polio as commonly called. This anxiety was cast out when Dr. Jonas Salk (1914-1995), American virologist and medical researcher, developed a vaccine against this disease.

Dr. Salk never patented his polio vaccine, but distributed the formula freely for the world to benefit from his discovery. He saved millions of people from death or alive but wheel-chair drawn.

Today, the Jonas Salk Institute for Biological Studies in California (La Jolla), continues his scientific work that include researches into diseases including cancer and HIV/AIDS.



Source:

Dateline.  New South Wales: Millennium House, 2006.